SARS-CoV-2 pseudovirus enters the host cells through spike protein-CD147 in an Arf6-dependent mannerSARS-CoV-2 슈도바이러스는 Arf6 의존적 방식으로 스파이크 단백질-CD147을 통해 숙주 세포에 들어갑니다.Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 approach Arf6 blockade CD147 cells clathrin Clathrin-mediated endocytosis clinically coronavirus endocytic endocytic mechanism endocytosis evaluate feasible function host cell host cells Huh-7 cell Huh-7 cells independent independent of indicated infected Vero E6 cells Infection inhibited inhibitor knockdown Localization macropinocytosis pathway Prevent pseudovirus pseudovirus infection public health RAB5A SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 pseudovirus SARS-CoV-2 pseudovirus infection severe acute respiratory syndrome Coronavirus Spike protein spike protein. Spread the SARS-CoV-2 variant Vero E6 VERO E6 cells viral infection weakened [DOI] 10.1080/22221751.2022.2059403 PMC 바로가기 [Article Type] Article
Theoretical investigation on the interactions of microplastics with a SARS-CoV-2 RNA fragment and their potential impacts on viral transport and exposureSARS-CoV-2 RNA 단편과 미세 플라스틱의 상호 작용 및 바이러스 수송 및 노출에 대한 잠재적 영향에 대한 이론적 조사Article Published on 2022-10-102022-09-11 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect affinity Behavior Behavior and fate cause condition coronavirus coronavirus disease Coronavirus disease-19 COVID-19 determine electrostatic environmental conditions Environmental pollution Evidence exposure to facilitate FIVE greater HBV hepatitis B Hepatitis B virus Human hydrophobic Impact independent independent of inherent Interaction involved Lungs mechanism media Microplastic pollution microplastics molecular molecular dynamic simulations molecular interaction molecular volume Nucleic acid material pandemic pandemic spread parameter polar risk RNA RNA fragment SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 transmission SARS-CoV-2. severe acute respiratory syndrome Coronavirus Spread strong interaction surface area temperature the SARS-CoV-2 Transport vacuum virus water [DOI] 10.1016/j.scitotenv.2022.156812 PMC 바로가기 [Article Type] Article
SARS-CoV-2 infections in infants in Haiti 2020-2021; evidence from a seroepidemiological cohort아이티 2020-2021년 유아의 SARS-CoV-2 감염; 혈청 역학 코호트의 증거Observational Study Published on 2022-08-252022-09-11 Journal: PLoS ONE [Category] SARS, 임상, 진단, 치료기술, 치료제, [키워드] age antibody Blood children Cohort collected country Course covariate COVID-19 case DBS sample DBS samples detectable ELISA estimate Evidence Frequency Haiti hazard highest independent independent of Infant Infants Infection initial less longitudinal samples over pandemic Patient patient age pregnant women prospective observational cohort Receptor binding domain reported Retrospective analysis S1 protein sampling SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S1 protein Seroconversion seroconversion rates serological response seropositive seropositive sample subsequent tested the SARS-CoV-2 [DOI] 10.1371/journal.pone.0273482 PMC 바로가기 [Article Type] Observational Study
Exploring the Impact of ACE Inhibition in Immunity and Disease면역 및 질병에 대한 ACE 억제의 영향 탐색Review Published on 2022-08-042022-09-11 Journal: Journal of the Renin-Angiotensin-Aldosterone Syste [Category] SARS, 치료기술, [키워드] ACE ACE inhibitor ACE inhibitors aldosterone Alter angiotensin Angiotensin II angiotensin receptor blocker Angiotensin receptor blockers Angiotensin-converting enzyme Antibiotic resistance Antigen presentation ARBs Arthritis Autoimmune autoimmune conditions Autoimmune disease Autoimmune diseases benefit Cancer Complication contribute coronavirus Diseases elevated enzyme highlight human neutrophil human neutrophils Immune cell immune cell populations immune cells immune regulation Immunocompromise Impact implicated independent independent of Infection Inflammation inflammatory immune cell inflammatory immune cells inhibition inhibitor Lupus Macrophage macrophages malignancy neurodegenerative Neutrophils no effect outcome overactive overexpression pandemic Patient phagocytosis RAAS Renin renin-angiotensin-aldosterone system Research responses rheumatoid arthritis risk ROS SARS-CoV2 therapeutic interventions understanding wake Zinc [DOI] 10.1155/2022/9028969 PMC 바로가기 [Article Type] Review
COVID-19 mRNA Vaccine in Patients With Lymphoid Malignancy or Anti-CD20 Antibody Therapy: A Systematic Review and Meta-Analysis림프성 악성종양 환자 또는 항-CD20 항체 치료 환자의 코로나19 mRNA 백신: 체계적인 검토 및 메타 분석Meta-Analysis Published on 2022-08-012022-09-11 Journal: Clinical lymphoma, myeloma & leukemia [Category] 치료제, [키워드] anti-CD20 antibody articles attenuate B-cell B-cell target therapy cellular response Cellular responses chronic lymphocytic leukemia CLL COVID-19 COVID-19 mRNA vaccine COVID-19 mRNA vaccines Effectiveness exhibited humoral Humoral and cellular responses Humoral response independent independent of individual leukemia Long-term follow-up Lymphocytic leukemia lymphoid lymphoma malignancies malignancy material Meta-analysis mRNA mRNA vaccine mRNA vaccines Myeloma Patient PROTECT registration number response to vaccination retrieved review risk risk ratio Seropositivity seropositivity. significantly subtype systematic review T cell T cell responses therapy These data vaccination Vaccine were used within 6 months [DOI] 10.1016/j.clml.2022.03.012 PMC 바로가기 [Article Type] Meta-Analysis
T-cell recovery and evidence of persistent immune activation 12 months after severe COVID-19심각한 COVID-19 이후 12개월 동안 T 세포 회복 및 지속적인 면역 활성화의 증거Article Published on 2022-08-012022-09-11 Journal: Allergy [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] accompanied acute infection administration analyzed assays Asymptomatic CD38 CD4 CD8 Characteristics clinical recovery coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccine Critical Cytometry dysregulated immune response enrolled Evidence evidence of exhibited exhibiting expression flow cytometry Follow-up functional hallmark HLA-DR immune activation impairment independent independent of individual Infection investigated lymphopenia Mild Most patients normalization Patient persistent phenotype phenotypic Post-infection pro-inflammatory cytokine proteomics recovery. SARS-CoV-2 severe COVID-19 severe COVID-19 patient severe COVID-19 patients subgroup of patient T cell T cells T-cell T-cell activation T-cell Response These cells timepoint viral antigens [DOI] 10.1111/all.15372 PMC 바로가기 [Article Type] Article
Human surfactant protein D facilitates SARS-CoV-2 pseudotype binding and entry in DC-SIGN expressing cells, and downregulates spike protein induced inflammation인간 계면활성제 단백질 D는 DC-SIGN 발현 세포에서 SARS-CoV-2 유사형 결합 및 진입을 촉진하고 스파이크 단백질 유도 염증을 하향 조절합니다Article Published on 2022-07-282022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료기술, [키워드] ACE2 Analysis Anti-viral binding carbohydrate cause Cell cell interaction cell line cell surface receptor cells chemokine chemokines collectins controls COVID-19 cytokine cytokine response Cytokines DC-SIGN dendritic cell domain downregulate downregulated eight epithelial expressing facilitate fragment of HEK 293T HEK293T cell HEK293T cells help Human IFN-α IL- 6 IL-1β IL-8 immune function immune response immunomodulatory effect increase independent independent of infection assay infection assays Inflammation inhibit SARS-CoV-2 innate immune innate immune system Interaction intercellular involved Macrophage macrophages MHC class MHC class II modulating mRNA expression mRNA level mRNA levels N-terminal naïve T cell naïve T cells NF-κB pathogen Pathogens pro-inflammatory cytokine pro-inflammatory cytokines Protein pseudotype RANTES receptors Replication rfhSP-D. RNA virus RT-qPCR SARS- CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication SARS-CoV-2 spike protein shown SIGN spike Spike protein surface receptor T cells the Spike THP-1 TNF-α treated Treatment Vero Cell Vero cells viral entry viruses [DOI] 10.3389/fimmu.2022.960733 PMC 바로가기 [Article Type] Article
Altered subgenomic RNA abundance provides unique insight into SARS-CoV-2 B.1.1.7/Alpha variant infections변경된 서브게놈 RNA 풍부도는 SARS-CoV-2 B.1.1.7/알파 변이체 감염에 대한 독특한 통찰력을 제공합니다Article Published on 2022-07-052022-09-11 Journal: Communications Biology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, 치료법, [키워드] Alpha Altered Antibody neutralization Applying ARTIC Network B.1.1.7 B.1.1.7 lineage B.1.177 Biology clinical samples Clinical severity complementary creating cycle threshold discontinuous transcription dominant lineage evaluate genomic genomic reads genomic sequencing greater hypothesise in vitro increase in independent independent of Infection Lineage lineages median Mutation nucleocapsid nucleotide Orf9b Oxford Nanopore Technology periscope positive produced profile protein level provide reductions in RNA sampling SARS-CoV-2 SARS-CoV-2 genome SARS-COV-2 infection SARS-CoV-2 infections sequence sgRNA significantly increased Support symptom onset the SARS-CoV-2 genome Transcription unique variant variants of concern virus [DOI] 10.1038/s42003-022-03565-9 PMC 바로가기 [Article Type] Article
Use of Tumor Necrosis Factor-α Antagonists Is Associated With Attenuated IgG Antibody Response Against SARS-CoV-2 in Vaccinated Patients With Inflammatory Bowel Disease종양 괴사 인자-α 길항제의 사용은 염증성 장 질환이 있는 백신 접종 환자에서 SARS-CoV-2에 대한 약화된 IgG 항체 반응과 관련이 있습니다Observational Study Published on 2022-07-052022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 임상, 진단, 치료기술, [키워드] Against age antagonist antagonists anti-SARS-CoV-2 antibody anti-SARS-CoV-2 vaccination antibody Antibody concentrations Antibody titer Antibody titers Biologicals Blood blood sampling bowel Characteristics clinical Clinical characteristics Combination completion Concentration COVID-19 Crohn's disease defined demonstrated detectable disease Effect elapsed geometric geometric mean IBD IgG IgG antibodies IgG antibody IgG antibody titer IgG antibody titers immune response immunoassay immunomodulating Immunosuppressive medication immunosuppressive medications increased risk independent independent of Inflammatory Inflammatory bowel disease medication Microparticle monotherapy Most patients mRNA mRNA vaccines mRNA-based vaccine mRNA-based vaccines Multivariable models Patient patient age patients patients treated prospective observational cohort quantitative determination RBD receive receiving Receptor-binding domain regimen response S1 subunit sampling SARS-CoV-2 SARS-COV-2 infection Seroconversion serological response significantly lower Spike protein the receptor-binding domain the S1 subunit the spike protein titer TNF-α-antagonists treated Treatment Tumor ulcerative colitis vaccination vaccination. Vaccine vector was used were measured were recorded [DOI] 10.3389/fimmu.2022.920333 PMC 바로가기 [Article Type] Observational Study
The role of routine SARS-CoV-2 screening of healthcare-workers in acute care hospitals in 2020: a systematic review and meta-analysis2020년 급성 치료 병원에서 의료 종사자의 일상적인 SARS-CoV-2 검사의 역할: 체계적인 검토 및 메타 분석Meta-Analysis Published on 2022-07-022022-09-11 Journal: BMC Infectious Diseases [Category] COVID19(2023년), SARS, 치료기술, [키워드] Asymptomatic Care Chain Reaction clinics Cochrane COVID-19 Study Register conducted coronavirus COVID COVID-19 Data collection described Early detection explained geographical region geographical regions HCW healthcare worker Healthcare workers Healthcare-workers heterogeneous hospital hotspot in some increased risk independent independent of indicate Infection infection control infection with SARS-CoV-2 medical treatment medical treatments Meta-analysis Nasopharyngeal swab pandemic Participants patient population PCR PCR testing polymerase chain polymerase chain reaction positive Positive test positive test result Prevalence prevention proportion ranged reduce reductions in reported risk of bia Sample size SARS-CoV-2 Screening Screening. sensitivity systematic review tested took place Transmission was performed Web of Science WHO [DOI] 10.1186/s12879-022-07554-5 PMC 바로가기 [Article Type] Meta-Analysis